发明授权
- 专利标题: Protease inhibitors
- 专利标题(中): 蛋白酶抑制剂
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申请号: US11410558申请日: 2006-04-25
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公开(公告)号: US07563784B2公开(公告)日: 2009-07-21
- 发明人: Maxwell D. Cummings , Robert W. Marquis, Jr. , Yu Ru , Scott K. Thompson , Daniel F. Veber , Dennis S. Yamashita
- 申请人: Maxwell D. Cummings , Robert W. Marquis, Jr. , Yu Ru , Scott K. Thompson , Daniel F. Veber , Dennis S. Yamashita
- 申请人地址: US PA King of Prussia
- 专利权人: SmithKline Beecham Corporation
- 当前专利权人: SmithKline Beecham Corporation
- 当前专利权人地址: US PA King of Prussia
- 代理商 Linda E. Hall; Alan Scrivner; Charles Kinzig
- 主分类号: A61P19/08
- IPC分类号: A61P19/08 ; A61P19/10 ; A61K31/55 ; C07D401/00 ; C07D403/00 ; C07D413/00
摘要:
The present invention provides C1-6alkyl-4-amino-azepan-3-one protease inhibitors and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, novel intermediates of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease; and parasitic diseases, including malaria, by administering to a patient in need thereof one or more compounds of the present invention.
公开/授权文献
- US20060194787A1 Protease inhibitors 公开/授权日:2006-08-31