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发明授权
US07566726B2 3,3-disubstituted tetrahydropyranyl cyclopentyl amide modulators of chemokine receptor activity 失效
趋化因子受体活性的3,3-二取代四氢吡喃基环戊基酰胺调节剂

3,3-disubstituted tetrahydropyranyl cyclopentyl amide modulators of chemokine receptor activity
摘要：
(wherein n, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R15, R16, R17, R18, Y and Z are defined herein) which are modulators of chemokine receptor activity and are useful in the prevention or treatment of certain inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which chemokine receptors are involved.
摘要（中）：

（其中n，R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 10，R 15，R 16，R 17，R 18，Y和Z在本文中定义），其是趋化因子受体活性的调节剂， 预防或治疗某些炎性和免疫调节性疾病和疾病，过敏性疾病，特应性病症，包括过敏性鼻炎，皮炎，结膜炎和哮喘，以及自身免疫病态如类风湿性关节炎和动脉粥样硬化。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及趋化因子受体的疾病中的用途。

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