发明授权
- 专利标题: Ascorbic acid derivatives and skin-whitening cosmetics
- 专利标题(中): 抗坏血酸衍生物和美白化妆品
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申请号: US11889158申请日: 2007-08-09
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公开(公告)号: US07569211B2公开(公告)日: 2009-08-04
- 发明人: Hiroharu Shibayama , Koichi Ueda , Hachiro Indo , Satoshi Tachibana , Hiroshi Nishikawa , Masaru Yamabe
- 申请人: Hiroharu Shibayama , Koichi Ueda , Hachiro Indo , Satoshi Tachibana , Hiroshi Nishikawa , Masaru Yamabe
- 申请人地址: JP Osaka-Shi JP Wakayama-Shi
- 专利权人: Toyo Beauty Co., Ltd.,Sugai Chemical Industry Co., Ltd.
- 当前专利权人: Toyo Beauty Co., Ltd.,Sugai Chemical Industry Co., Ltd.
- 当前专利权人地址: JP Osaka-Shi JP Wakayama-Shi
- 代理机构: Wenderoth, Lind & Ponack, LLP.
- 优先权: JP2004-089876 20040325; JP2004-089893 20040325
- 主分类号: A61Q5/08
- IPC分类号: A61Q5/08
摘要:
It is an object to provide an L-ascorbic acid derivative which can keep the L-ascorbic acid stable to heat and light and thus has a long shelf life, which is high in permeability into the skin, which can be quickly hydrolyzed by phosphatase, an enzyme that is ubiquitous in vivo, and which exhibits physiological activities that are inherent to L-ascorbic acid and beneficial to health, a method for producing such an L-ascorbic acid derivative, and a skin-whitening cosmetic material.There is provided an ascorbic acid derivative comprising an L-ascorbic acid-2-phosphate ester or a salt thereof wherein the phosphate ester has a branched alkyl group, the L-ascorbic acid-2-phosphate ester being of formula [13]. The ascorbic acid derivative is produced by a method comprising reacting a branched alkanol with phosphorus oxychloride to synthesize monoalkyldichlorophosphate or dialkylmonochlorophosphate, reacting the thus obtained substance with 5,6-O-isopropylidene-L-ascorbic acid obtained by reacting L-ascorbic acid with acetone, and subjecting the thus obtained substance to acid hydrolysis. There is also provided a cosmetic material containing such an ascorbic acid derivative by 0.05 to 80 percent by weight. (wherein each of R1 and R2 is a hydrogen (H) atom or an alkyl group having branches and including 3 to 30 carbon atoms, but not both of R1 and R2 are hydrogen (H) atoms)
公开/授权文献
- US20080253982A1 Ascorbic acid derivatives and skin-whitening cosmetics 公开/授权日:2008-10-16