发明授权
US07569567B2 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-B]indole-1-carboxamide derivatives, their preparation and therapeutic use
有权
3-杂芳基-3,5-二氢-4-氧代-4H-哒嗪并[4,5-b]吲哚-1-甲酰胺衍生物,其制备和治疗用途
- 专利标题: 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-B]indole-1-carboxamide derivatives, their preparation and therapeutic use
- 专利标题(中): 3-杂芳基-3,5-二氢-4-氧代-4H-哒嗪并[4,5-b]吲哚-1-甲酰胺衍生物,其制备和治疗用途
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申请号: US12140608申请日: 2008-06-17
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公开(公告)号: US07569567B2公开(公告)日: 2009-08-04
- 发明人: Philippe Burnier , Jacques Froissant , Benoit Marabout , Frank Marguet , Frederic Puech
- 申请人: Philippe Burnier , Jacques Froissant , Benoit Marabout , Frank Marguet , Frederic Puech
- 申请人地址: FR Paris
- 专利权人: sanofi-aventis
- 当前专利权人: sanofi-aventis
- 当前专利权人地址: FR Paris
- 代理商 Kelly L. Bender
- 优先权: FR0116701 20011221
- 主分类号: A61K31/503
- IPC分类号: A61K31/503 ; C07D487/02
摘要:
A subject-matter of the invention is the compounds of general formula (I) in which X represents a hydrogen or halogen atom; R1 represents a hydrogen atom or a (C1-C4)alkyl group; R2 and R3 each represent, independently of one another, a hydrogen atom or a (C1-C4)alkyl group or else R2 and R3 form, with the nitrogen atom which carries them, a pyrrolidinyl, piperidinyl, morpholinyl or 4-alkylpiperazinyl group; and Het represents a heteroaromatic group of pyridinyl, 1-oxidopyridinyl, quinolinyl, isoquinolinyl, pyrimidinyl, pyrazinyl or pyridazinyl type, it being possible for the heteroaromatic group to carry one or more halogen atoms and/or one or more (C1-C4) alkyl or (C1-C4) alkoxy groups; in the form of bases, of addition salts with acids, of solvates or of hydrates, the pharmaceutical compositions comprising them, processes for their preparation and synthetic intermediates.
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