A method for determining a fresh fuel bundle design for a core of a nuclear reactor may include defining a plurality of inputs including user-defined target conditions for evaluating one or more reference fresh fuel bundle designs for each of N bundle groups, and generating a response surface based on making single rod-type changes in each (i,j) rod location of each bundle of a given reference bundle design being evaluated for each of the N bundle groups. A search algorithm may be iterated to evaluate a given combination of multiple rod-type changes made simultaneously across each of the N bundle groups using the generated response surface to determine an accepted fuel bundle design for each of the N bundle groups that satisfies the user-defined target conditions.