发明授权
US07576064B2 Pyrazole derivative, drug composition containing the same and production intermediate therefor
失效
吡唑衍生物,含有它们的药物组合物及其制备中间体
- 专利标题: Pyrazole derivative, drug composition containing the same and production intermediate therefor
- 专利标题(中): 吡唑衍生物,含有它们的药物组合物及其制备中间体
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申请号: US10561217申请日: 2004-06-15
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公开(公告)号: US07576064B2公开(公告)日: 2009-08-18
- 发明人: Norihiko Kikuchi , Hideki Fujikura , Shigeki Tazawa , Tokuhisa Yamato , Masayuki Isaji
- 申请人: Norihiko Kikuchi , Hideki Fujikura , Shigeki Tazawa , Tokuhisa Yamato , Masayuki Isaji
- 申请人地址: JP Nagano
- 专利权人: Kissei Pharmaceutical Co., Ltd.
- 当前专利权人: Kissei Pharmaceutical Co., Ltd.
- 当前专利权人地址: JP Nagano
- 代理机构: Sughrue Mion, PLLC
- 优先权: JP2003-175663 20030620
- 国际申请: PCT/JP2004/008695 WO 20040615
- 国际公布: WO2004/113359 WO 20041229
- 主分类号: A01N43/04
- IPC分类号: A01N43/04 ; A61K31/70 ; C07H17/00
摘要:
The present invention provides pyrazole derivatives represented by the general formula: wherein R1 represents H, an optionally substituted C1-6 alkyl, etc.; one of Q and T represents a group selected from the following: and the other represents -Z-Ar wherein Z represents —O—, —S—, etc.; Ar represents an optionally substituted C6-10 aryl, etc.; R represents an optionally substituted C3-8 cycloalkyl, an optionally substituted C6-10 aryl, etc., pharmaceutically acceptable salts thereof, and prodrugs thereof, which exhibit an excellent inhibitory activity in human sodium/glucose cotransporter (SGLT) and are useful as agents for the prevention, inhibition of progression or treatment of a disease associated with the excess uptake of at least a kind of carbohydrates selected from glucose, fructose and mannose (diabetes, postprandial hyperglycemia, impaired glucose tolerance, diabetic complications, etc.), and pharmaceutical compositions containing the same, medicinal uses thereof and intermediates for production therefor.
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