发明授权
- 专利标题: Androstane 17α-carbonate derivatives for use in the treatment of allergic and inflammatory conditions
- 专利标题(中): 雄甾烷17α-碳酸酯衍生物用于治疗过敏和炎症状况
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申请号: US11813227申请日: 2006-01-09
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公开(公告)号: US07579335B2公开(公告)日: 2009-08-25
- 发明人: Keith Biggadike , Deborah Needham
- 申请人: Keith Biggadike , Deborah Needham
- 申请人地址: GB Greenford, Middlesex
- 专利权人: Glaxo Group Limited
- 当前专利权人: Glaxo Group Limited
- 当前专利权人地址: GB Greenford, Middlesex
- 代理商 James P. Riek
- 优先权: GB0500405.6 20050110; GB0518774.5 20050914
- 国际申请: PCT/EP2006/000149 WO 20060109
- 国际公布: WO2006/072599 WO 20060713
- 主分类号: A61K31/56
- IPC分类号: A61K31/56 ; C07J3/00
摘要:
The present invention is directed to compounds of formula (I): wherein R1 represents C4-C7 branched alkyl group, a bicycloalkyl group, or a C5-C6 cycloalkyl which optionally may be substituted with a C1-C4 alkyl group; R2 represents hydrogen, a methyl group, which may be in either the α or β configuration, or a methylene group; R3 and R4 are the same or a different group and each independently represents hydrogen, halogen or a methyl group; represents a single or a double bond; and physiologically acceptable solvates thereof, physiologically functional derivatives thereof, pharmaceutical compositions comprising the compounds, the use of the compounds for the manufacture of medicaments particularly for the treatment of inflammatory and/or allergic conditions, processes for the preparation of the compounds, and chemical intermediates in the processes for the manufacture of the compounds.
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