A method and system for handling of potential unsafe instructions and/or for handling transfers of control in a Virtual Machine, that includes generating a frame composed of pages of analyzed code based on original guest code; identifying instructions within the frame that transfer control (or are otherwise unsafe); replacing instructions that transfer the control with an interrupt that transfers control to a stub in non-privileged code; wherein the stub checks whether the control transfer (or instruction) is safe or unsafe, and (i) for unsafe control transfers/unsafe instructions, switches the context to Virtual Machine Monitor; and (ii) for safe control transfers, executes the control transfer in non-privileged mode. The instructions that transfer control can include any of JMP, CALL, RET and RET(n). The instructions that transfer control can also include interrupts.