Invention Grant
- Patent Title: Purine derivatives
- Patent Title (中): 嘌呤衍生物
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Application No.: US11033692Application Date: 2005-01-11
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Publication No.: US07582642B2Publication Date: 2009-09-01
- Inventor: Peter Martin Fischer , Michael Jarman , Edward McDonald , Bernard Nutley , Florence Raynaud , Stuart Wilson , Paul Workman
- Applicant: Peter Martin Fischer , Michael Jarman , Edward McDonald , Bernard Nutley , Florence Raynaud , Stuart Wilson , Paul Workman
- Applicant Address: GB Dundee GB London
- Assignee: Cyclacel Limited,Cancer Research Technology Limited
- Current Assignee: Cyclacel Limited,Cancer Research Technology Limited
- Current Assignee Address: GB Dundee GB London
- Agency: Lahive & Cockfield, LLP
- Agent Cynthia L. Kanik; Brian C. Trinque
- Main IPC: C07D473/16
- IPC: C07D473/16 ; A61K31/52 ; A61P35/00 ; A61P31/14 ; A61P31/20 ; C07D473/40

Abstract:
The present invention relates to compounds of formula 1 or pharmaceutically acceptable salts thereof, wherein one of R1 and R2 is methyl, ethyl or isopropyl, and the other is H; R3 and R4 are each independently H, branched or unbranched C1-C6 alkyl, or aryl, and wherein at least one of R3 and R4 is other than H; R5 is a branched or unbranched C1-C5 alkyl group or a C1-C6 cycloalkyl group, each of which may be optionally substituted with one or more OH groups; R6, R7, R8 and R9 are each independently H, halogen, NO2, OH, OMe, CN, NH2, COOH, CONH2, or SO2NH2. A further aspect of the invention relates to pharmaceutical compositions comprising compounds of formula 1, and the use of said compounds in treating proliferative disorders, viral disorders, stroke, alopecia, CNS disorders, neurodegenerative disorders, or diabetes.
Public/Granted literature
- US20050256142A1 New purine derivatives Public/Granted day:2005-11-17
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