Methods and systems for digitally controlling transmitter gain compensation are disclosed. Aspects of one method may include applying an effective negative resistance to differential outputs of amplifying circuitry to compensate for gain changes that may be due to temperature changes. The effective negative resistance may be provided via a plurality of load circuits coupled in parallel to the differential outputs. The plurality of load circuits may have similar effective negative resistances, or the plurality of load circuits may be binary weighted. Each load circuit may be selected via digital control signals that may enable the load circuit. This may allow adjusting of the effective negative resistance by selecting different load circuits.