An method of synchronizing a signal coming from at least one sensor positioned on an engine with a periodic event of the engine such as the crankshaft rotation is disclosed having application for engine control. A crankshaft rotation signal indicative of a reference time (TR), with which the engine signal(s) is to be synchronized, is acquired. The effective time difference (D) between the reference time and the time that is the closest to each temporally acquired engine signal is measured. Then the coefficients of a fractional digital compensation filter (FSDF) for compensating for the fractional part (d) of the measured effective time difference are determined. Finally, this digital compensation filter is applied to each temporally sampled engine signal, allowing obtaining of a series of digitized samples resealed from reference time (TR) for each engine signal.