发明授权
US07585841B2 Methods and compositions useful for modulation of angiogenesis using tyrosine kinase Src
失效
使用酪氨酸激酶Src调节血管发生的方法和组合物
- 专利标题： Methods and compositions useful for modulation of angiogenesis using tyrosine kinase Src
- 专利标题（中）： 使用酪氨酸激酶Src调节血管发生的方法和组合物
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申请号： US11230995申请日： 2005-09-19
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公开(公告)号： US07585841B2公开(公告)日： 2009-09-08
- 发明人: David A. Cheresh , Brian Eliceiri , Pamela L. Schwartzberg
- 申请人： David A. Cheresh , Brian Eliceiri , Pamela L. Schwartzberg
- 申请人地址： US CA La Jolla US DC Washington
- 专利权人： The Scripps Research Institute,The United States of America as represented by the Department of Health and Human Services
- 当前专利权人： The Scripps Research Institute,The United States of America as represented by the Department of Health and Human Services
- 当前专利权人地址： US CA La Jolla US DC Washington
- 代理机构： Olson & Cepuritis, Ltd.
- 主分类号： A61K38/00
- IPC分类号： A61K38/00
摘要：
The present invention describes methods for modulating angiogenesis in tissues using Src protein, modified Src protein, and nucleic acids encoding for such. Particularly the invention describes methods for inhibiting angiogenesis using an inactive Src protein, or nucleic acids encoding therefor, or for potentiating angiogenesis using an active Src protein, or nucleic acids encoding therefor. The invention also describes the use of gene delivery systems for providing nucleic acids encoding for the Src protein, or modified forms thereof.
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