Invention Grant
US07589085B2 Tetrahydropyran heterocyclic cyclopentyl heteroaryl modulators of chemokine receptor activity
失效
趋化因子受体活性的四氢吡喃杂环环戊基杂芳基调节剂
- Patent Title: Tetrahydropyran heterocyclic cyclopentyl heteroaryl modulators of chemokine receptor activity
- Patent Title (中): 趋化因子受体活性的四氢吡喃杂环环戊基杂芳基调节剂
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Application No.: US10567516Application Date: 2004-08-06
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Publication No.: US07589085B2Publication Date: 2009-09-15
- Inventor: Gabor Butora , Lihu Yang , Stephen D. Goble
- Applicant: Gabor Butora , Lihu Yang , Stephen D. Goble
- Applicant Address: US NJ Rahway
- Assignee: Merck & Co., Inc.
- Current Assignee: Merck & Co., Inc.
- Current Assignee Address: US NJ Rahway
- Agent Mark R. Daniel; James L. McGinnis
- International Application: PCT/US2004/025467 WO 20040806
- International Announcement: WO2005/014537 WO 20050217
- Main IPC: C07D401/02
- IPC: C07D401/02 ; A61K31/44
Abstract:
The present invention is further directed to compounds of the formulas: (I) (II) (wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R15, R16, R17, R18, R19, R24 and R25 are as defined herein) which are modulators of chemokine receptor activity and are useful in the prevention or treatment of certain inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which chemokine receptors are involved.
Public/Granted literature
- US20060205783A1 Tetrahydropyran heterocyclic cyclopentyl heteroaryl modulators of chemokine receptor activity Public/Granted day:2006-09-14
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