发明授权
US07589237B2 Treatment of CNS disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine
有权
用反式4-（3,4-二氯苯基）-1,2,3,4-四氢-1-萘胺处理CNS病症
- 专利标题： Treatment of CNS disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine
- 专利标题（中）： 用反式4-（3,4-二氯苯基）-1,2,3,4-四氢-1-萘胺处理CNS病症
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申请号： US12173626申请日： 2008-07-15
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公开(公告)号： US07589237B2公开(公告)日： 2009-09-15
- 发明人: Thomas Jerussi , Qun Kevin Fang , Mark G. Currie
- 申请人： Thomas Jerussi , Qun Kevin Fang , Mark G. Currie
- 申请人地址： US MA Marlborough
- 专利权人： Sepracor Inc.
- 当前专利权人： Sepracor Inc.
- 当前专利权人地址： US MA Marlborough
- 代理机构： Heslin Rothenberg Farley & Mesiti P.C.
- 主分类号： C07C211/45
- IPC分类号： C07C211/45 ; C07C233/15 ; A61K31/135 ; A61K31/03 ; A61K31/165
摘要：
Treatment of CNS disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine; and (1S,4R)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is disclosed. A process for preparing 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is also disclosed. The process includes the preparation of all four isomers of N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]formamide, which are also useful.
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