发明授权
- 专利标题： Quinoline derivatives and quinazoline derivatives inhibiting autophosphorylation of macrophage colony stimulating factor receptor
- 专利标题（中）： 喹啉衍生物和喹唑啉衍生物抑制巨噬细胞集落刺激因子受体的自磷酸化
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申请号： US10510961申请日： 2003-05-01
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公开(公告)号： US07598258B2公开(公告)日： 2009-10-06
- 发明人: Kazuo Kubo , Hiroaki Ohno , Toshiyuki Isoe , Tuyoshi Nishitoba
- 申请人： Kazuo Kubo , Hiroaki Ohno , Toshiyuki Isoe , Tuyoshi Nishitoba
- 申请人地址： JP Tokyo-To
- 专利权人： Kirin Beer Kabushiki Kaisha
- 当前专利权人： Kirin Beer Kabushiki Kaisha
- 当前专利权人地址： JP Tokyo-To
- 代理机构： Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- 优先权： JP2002-130049 20020501
- 国际申请： PCT/JP03/05593 WO 20030501
- 国际公布： WO03/093238 WO 20031113
- 主分类号： C07D215/38
- IPC分类号： C07D215/38 ; A61K31/44
摘要：
An objective of the present invention is to provide compounds which have inhibitory activity against autophosphorylation of macrophage colony-stimulating factor receptors. The compounds of the present invention are represented by formula (I) and salt and solvate thereof: wherein X represents CH or N; Z represents O or S; R1, R2, and R3 represent H, optionally substituted alkoxy or the like; R4 represents H; R5, R6, R7, and R8 represent H, halogen, alkyl, alkoxy, trifluoromethyl or the like; R9 and R10 represent H, alkyl or the like; and any one of R11 and R12 represents H with the other representing alkyl and R13 represents an optionally substituted carbocyclic or heterocyclic ring or the like, or R11 represents H and R12 and R13 combine together to form a bicyclic carbocyclic ring.
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