发明授权
- 专利标题: HIV integrase inhibitors
- 专利标题(中): HIV整合酶抑制剂
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申请号: US10587682申请日: 2005-03-09
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公开(公告)号: US07598264B2公开(公告)日: 2009-10-06
- 发明人: Wei Han , Melissa Egbertson , John S. Wai , Linghang Zhuang , Rowena D. Ruzek , Debra S. Perlow , Mark Cameron , Bruce S. Foster , Ulf H. Dolling , R. Scott Hoerrner , Philip J. Pye , Remy Angelaud , Danny E. Mancheno , David Askin
- 申请人: Wei Han , Melissa Egbertson , John S. Wai , Linghang Zhuang , Rowena D. Ruzek , Debra S. Perlow , Mark Cameron , Bruce S. Foster , Ulf H. Dolling , R. Scott Hoerrner , Philip J. Pye , Remy Angelaud , Danny E. Mancheno , David Askin
- 申请人地址: US NJ Rahway
- 专利权人: Merck & Co., Inc.
- 当前专利权人: Merck & Co., Inc.
- 当前专利权人地址: US NJ Rahway
- 代理商 Kenneth R. Walton; Sheldon O. Heber
- 国际申请: PCT/US2005/007772 WO 20050309
- 国际公布: WO2005/087768 WO 20050922
- 主分类号: A01N43/42
- IPC分类号: A01N43/42 ; A61K31/44 ; C07D471/02 ; C07D491/02 ; C07D498/02 ; C07D513/02
摘要:
Hydroxy (tetra- or hexa-)hydronaphthyridine dione compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: (I) wherein a, R1?, R2?, R3?, R4? and R5? are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
公开/授权文献
- US20070179196A1 Hiv integrase inhibitors 公开/授权日:2007-08-02