发明授权
- 专利标题： Methods for synthesis of 3-amino-1-arylpropyl indoles
- 专利标题（中）： 合成3-氨基-1-芳基丙基吲哚的方法
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申请号： US11605648申请日： 2006-11-29
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公开(公告)号： US07598399B2公开(公告)日： 2009-10-06
- 发明人: Terrence Joseph Connolly , Robert P. Farrell , Eric Roy Humphreys , Stephen M. Lynch , Keshab Sarma
- 申请人： Terrence Joseph Connolly , Robert P. Farrell , Eric Roy Humphreys , Stephen M. Lynch , Keshab Sarma
- 申请人地址： US CA Palo Alto
- 专利权人： Roche Palo Alto LLC
- 当前专利权人： Roche Palo Alto LLC
- 当前专利权人地址： US CA Palo Alto
- 代理商 Robert C. Hall
- 主分类号： C07D209/18
- IPC分类号： C07D209/18
摘要：
A method comprising: hydrogenating an indole propionamide compound of formula h with vitride, to form an aminopropyl indole compound of formula i wherein m, Ar, R1 and R2 are as defined herein. The compounds prepared by the method of the invention are useful as monoamine reuptake inhibitors useful for treatment of CNS indications.
公开/授权文献
- US20070135647A1 Methods for synthesis of 3-amino-1-arylpropyl indoles 公开/授权日：2007-06-14