发明授权
US07601124B2 Complexity-based dynamical assay for assessing the toxicity and efficacy of pharmaceutical and other therapeutic interventions
失效
用于评估药物和其他治疗干预措施的毒性和功效的基于复杂性的动力学测定
- 专利标题: Complexity-based dynamical assay for assessing the toxicity and efficacy of pharmaceutical and other therapeutic interventions
- 专利标题(中): 用于评估药物和其他治疗干预措施的毒性和功效的基于复杂性的动力学测定
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申请号: US11356044申请日: 2006-02-17
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公开(公告)号: US07601124B2公开(公告)日: 2009-10-13
- 发明人: Ary L. Goldberger , Chung-Kang Peng , Madalena D. Costa
- 申请人: Ary L. Goldberger , Chung-Kang Peng , Madalena D. Costa
- 申请人地址: US MA Boston
- 专利权人: Beth Israel Deaconess Medical Center
- 当前专利权人: Beth Israel Deaconess Medical Center
- 当前专利权人地址: US MA Boston
- 代理机构: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- 主分类号: A61B5/02
- IPC分类号: A61B5/02
摘要:
In a subject undergoing therapeutic intervention, efficacy of the therapeutic intervention is assessed based on a series of physiologic data associated with the subject. The series of physiologic data is analyzed to produce a measure of complexity. The complexity measure is then compared to a control. The efficacy of the therapeutic intervention is assessed based on the comparison of the complexity measure to the control. The control may be, for example, a complexity measure taken prior to initiation of the therapeutic intervention, a complexity measure taken from a different subject, or a predetermined threshold value. The measure of complexity is generated using, for example, a multiscale entropy measurement (MSE), a time asymmetry measurement, and/or an information-based similarity measurement. An increase in complexity indicates a positive effect of the therapeutic intervention, while a decrease in complexity indicates a negative effect of the therapeutic intervention.