发明授权
- 专利标题： Heterocyclic NF-kB inhibitors
- 专利标题（中）： 杂环NF-kB抑制剂
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申请号： US11375259申请日： 2006-03-15
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公开(公告)号： US07601745B2公开(公告)日： 2009-10-13
- 发明人: Johann Leban , Harald Schmitt , Kristina Wolf , Stefano Pegoraro , Andreas Wuzik
- 申请人： Johann Leban , Harald Schmitt , Kristina Wolf , Stefano Pegoraro , Andreas Wuzik
- 申请人地址： DE Martinsreid
- 专利权人： 4SC AG
- 当前专利权人： 4SC AG
- 当前专利权人地址： DE Martinsreid
- 代理机构： Baker, Donelson, Bearman, Caldwell and Berkowitz, P.C.
- 主分类号： A01N43/52
- IPC分类号： A01N43/52 ; A01N43/78 ; A61K31/415 ; A61K31/425 ; C07D235/04 ; C07D263/58 ; C07D263/60 ; C07D277/82 ; C07D403/02 ; C07D413/00 ; C07D498/00
摘要：
The present invention relates to compounds of the general formula (III) or pharmaceutically acceptable salts thereof with an acid or a base, or pharmaceutically acceptable prodrugs or a stereoisomer thereof, wherein R3 is H, —C(O)NRaRb, halogen, alkyl, haloalkyl, aryl, heteroaryl, OH, SH, NR4′OR5′, NH2, amine, alkylamine, alkoxy, cycloalkyl, heterocycloalkyl, hydroxyalkyl, or haloalkyloxy; R4 is H, halogen, alkyl, —C(NR7)NR7R8, —(CH2)paryl, —(CH2)pNR7R8, —C(O)NR7R8, —N═CR7R8, —NR7C(O)R8, cycloalkyl, heterocycloalkyl, haloalkyl, hydroxyalkyl, hyodroxyalkylamino, alkylamino, heteroaryl, or aryl; R5 is halogen, alkyl, —C(NR7)NR7R8, —(CH2)paryl, —(CH2)pNR7R8, —C(O)NR7R8, —N═CR7R8, —NR7C(O)R8, cycloalkyl, heterocycloalkyl, haloalkyl, hydroxyalkyl, hydroxyalkylamino, alkylamino, heteroaryl, or aryl.
公开/授权文献
- US20060247253A1 Novel heterocyclic NF-kB inhibitors 公开/授权日：2006-11-02
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