发明授权
- 专利标题： PDE4B inhibitors
- 专利标题（中）： PDE4B抑制剂
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申请号： US11219635申请日： 2005-09-02
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公开(公告)号： US07605168B2公开(公告)日： 2009-10-20
- 发明人: Prabha N. Ibrahim , Ryan Bremer , Sam Gillette , Hanna Cho , Marika Nespi , Shumeye Mamo , Chao Zhang , Dean R. Artis , Byunghun Lee , Rebecca Zuckerman
- 申请人： Prabha N. Ibrahim , Ryan Bremer , Sam Gillette , Hanna Cho , Marika Nespi , Shumeye Mamo , Chao Zhang , Dean R. Artis , Byunghun Lee , Rebecca Zuckerman
- 申请人地址： US CA Berkeley
- 专利权人： Plexxikon, Inc.
- 当前专利权人： Plexxikon, Inc.
- 当前专利权人地址： US CA Berkeley
- 代理机构： Foley & Lardner LLP
- 主分类号： A61K31/437
- IPC分类号： A61K31/437 ; A61K31/403 ; C07D471/02 ; C07D405/02
摘要：
Compounds are described that are active on PDE4. Also described are crystal structures of PDE4B determined using X-ray crystallography, the use of PDE4B crystals and structural information for identifying molecular scaffolds, for developing ligands that bind to and modulate PDE4B, and for identifying improved ligands based on known ligands.
公开/授权文献
- US20060100218A1 PDE4B inhibitors 公开/授权日：2006-05-11