Invention Grant
US07605270B2 Polymorphic forms of (S).-tetrahydrofuran-3-yl-3-(3-(3-methoxy-4-(oxazol-5-yl) phenyl) ureido) benzylcarbamate
失效
（S）-1-四氢呋喃-3-基-3-（3-（3-甲氧基-4-（恶唑-5-基）苯基）脲基）苄基氨基甲酸酯的多晶型
- Patent Title: Polymorphic forms of (S).-tetrahydrofuran-3-yl-3-(3-(3-methoxy-4-(oxazol-5-yl) phenyl) ureido) benzylcarbamate
- Patent Title (中): （S）-1-四氢呋喃-3-基-3-（3-（3-甲氧基-4-（恶唑-5-基）苯基）脲基）苄基氨基甲酸酯的多晶型
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Application No.: US11429811Application Date: 2006-05-08
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Publication No.: US07605270B2Publication Date: 2009-10-20
- Inventor: Todd Blythe , Alex Eberlin , Michael Hurrey , David Jonaitis , Philip Nyce , Stephan Parent , John Snoonian
- Applicant: Todd Blythe , Alex Eberlin , Michael Hurrey , David Jonaitis , Philip Nyce , Stephan Parent , John Snoonian
- Applicant Address: US MA Cambridge
- Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee Address: US MA Cambridge
- Agent Michael C. Badia
- Main IPC: C07D263/32
- IPC: C07D263/32
Abstract:
The present invention relates to polymorphic forms of (S)-tetrahydrofuran-3-yl 3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)benzylcarbamate (Compound 1): and pharmaceutical compositions thereof. The present invention also relates to processes to prepare compound 1 and pharmaceutical compositions thereof. Compound 1 is an IMPDH inhibitor useful in treating IMPDH-mediated diseases such as immune system related diseases, viral diseases, and cancers.
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