Invention Grant
US07611854B2 Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor
失效
酵母细胞工程化生产信息素系统蛋白质代理，并用于此
- Patent Title: Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor
- Patent Title (中): 酵母细胞工程化生产信息素系统蛋白质代理，并用于此
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Application No.: US10600003Application Date: 2003-06-18
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Publication No.: US07611854B2Publication Date: 2009-11-03
- Inventor: Dana M. Fowlkes , Jim Broach , John Manfredi , Christine Klein , Andrew J. Murphy , Jeremy Paul , Joshua Trueheart
- Applicant: Dana M. Fowlkes , Jim Broach , John Manfredi , Christine Klein , Andrew J. Murphy , Jeremy Paul , Joshua Trueheart
- Applicant Address: US NY New York
- Assignee: Cadus Technologies, Inc.
- Current Assignee: Cadus Technologies, Inc.
- Current Assignee Address: US NY New York
- Agency: Edwards Angell Palmer & Dodge LLP
- Agent Peter C. Lauro, Esq.; Melissa Hunter-Ensor, Esq.
- Main IPC: C12N1/19
- IPC: C12N1/19 ; G01N33/53
Abstract:
Yeast cells are engineered to express both a surrogate of a pheromone system protein (e.g., enzymes involved in maturation of α-factor, transporters of a-factor, pheromone receptors, etc.) and a potential peptide modulator of the surrogate, in such a manner that the inhibition or activation of the surrogate affects a screenable or selectable trait of the yeast cells. Various additional features improve the signal-to-noise ratio of the screening/selection system.
Public/Granted literature
- US20040197840A1 Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor Public/Granted day:2004-10-07
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