发明授权
US07611854B2 Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor
失效
酵母细胞工程化生产信息素系统蛋白质代理，并用于此
- 专利标题： Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor
- 专利标题（中）： 酵母细胞工程化生产信息素系统蛋白质代理，并用于此
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申请号： US10600003申请日： 2003-06-18
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公开(公告)号： US07611854B2公开(公告)日： 2009-11-03
- 发明人: Dana M. Fowlkes , Jim Broach , John Manfredi , Christine Klein , Andrew J. Murphy , Jeremy Paul , Joshua Trueheart
- 申请人： Dana M. Fowlkes , Jim Broach , John Manfredi , Christine Klein , Andrew J. Murphy , Jeremy Paul , Joshua Trueheart
- 申请人地址： US NY New York
- 专利权人： Cadus Technologies, Inc.
- 当前专利权人： Cadus Technologies, Inc.
- 当前专利权人地址： US NY New York
- 代理机构： Edwards Angell Palmer & Dodge LLP
- 代理商 Peter C. Lauro, Esq.; Melissa Hunter-Ensor, Esq.
- 主分类号： C12N1/19
- IPC分类号： C12N1/19 ; G01N33/53
摘要：
Yeast cells are engineered to express both a surrogate of a pheromone system protein (e.g., enzymes involved in maturation of α-factor, transporters of a-factor, pheromone receptors, etc.) and a potential peptide modulator of the surrogate, in such a manner that the inhibition or activation of the surrogate affects a screenable or selectable trait of the yeast cells. Various additional features improve the signal-to-noise ratio of the screening/selection system.
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