发明授权
- 专利标题: Diazabicyclic aryl derivatives as cholinergy ligands
- 专利标题(中): 二氮杂双环芳基衍生物作为胆碱能配体
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申请号: US11663967申请日: 2005-11-29
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公开(公告)号: US07612074B2公开(公告)日: 2009-11-03
- 发明人: Dan Peters , Daniel B. Timmermann , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Tino Dyhring Jørgensen
- 申请人: Dan Peters , Daniel B. Timmermann , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Tino Dyhring Jørgensen
- 申请人地址: DK Ballerup
- 专利权人: Neurosearch A/S
- 当前专利权人: Neurosearch A/S
- 当前专利权人地址: DK Ballerup
- 代理机构: Birch, Stewart, Kolasch & Birch, LLP
- 优先权: DK200401863 20041130
- 国际申请: PCT/EP2005/056300 WO 20051129
- 国际公布: WO2006/058879 WO 20060608
- 主分类号: A61K31/497
- IPC分类号: A61K31/497
摘要:
This invention relates to novel diazabicyclic aryl compounds of the formula wherein: R′ represents hydrogen or alkyl; A represents an aromatic monocyclic or bicyclic carbocyclic or heterocyclic; and is hydrogen or a subsituent as defined in the specification. The compounds are cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. The compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.