发明授权
- 专利标题: 2-phenylthiophene derivative
- 专利标题(中): 2-苯基噻吩衍生物
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申请号: US11661294申请日: 2005-08-26
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公开(公告)号: US07612108B2公开(公告)日: 2009-11-03
- 发明人: Junji Miyata , Masaki Yokota , Ryo Naito , Akio Kamikawa , Masakatsu Kawakami , Kazuyuki Hattori
- 申请人: Junji Miyata , Masaki Yokota , Ryo Naito , Akio Kamikawa , Masakatsu Kawakami , Kazuyuki Hattori
- 申请人地址: JP Tokyo
- 专利权人: Astellas Pharma Inc.
- 当前专利权人: Astellas Pharma Inc.
- 当前专利权人地址: JP Tokyo
- 代理机构: Sughrue Mion, PLLC
- 优先权: JP2004-249276 20040827
- 国际申请: PCT/JP2005/015550 WO 20050826
- 国际公布: WO2006/022375 WO 20060302
- 主分类号: A61K31/381
- IPC分类号: A61K31/381 ; C07D333/16
摘要:
The present invention relates to a 2-phenylthiophene derivative or a salt thereof, wherein the thiophene ring is substituted with a carboxyl group or the like and the benzene ring has an electron-withdrawing group such as a cyano group and an electron-donating group such as a substituted alkoxy group at the same time. Since the compound of the invention has good xanthine oxidase-inhibitory action and uric acid-lowering action and does not have a structure derived from nucleic acid, the compound has advantages of high safety and excellent effects as compared with conventional compounds and is useful as a therapeutic or preventive agent for hyperuricemia, gout, inflammatory bowel diseases, diabetic kidney diseases, diabetic retinopathy, or the like.
公开/授权文献
- US20080027048A1 2-Phenylthiophene Derivative 公开/授权日:2008-01-31