A Craniofacial Fracture Reduction Assembly may include a reduction platform, a threaded fragment manipulator, and an adjustable support assembly. The reduction platform has at least one receiving hole configured to accept a fragment manipulator. The fragment manipulator may comprise an elongated member having a bone engaging portion for engaging a targeted fractured bone piece and a center threaded portion. In use, the bone engaging end of the fragment manipulator is inserted through the receiving hole in the reduction platform and then into the fracture region where it engages the targeted fractured bone piece. Thereafter a reduction nut is threaded onto the non-engaged end of the fragment manipulator until the nose of the nut contacts the reduction platform. Continued rotation of the nut causes the fragment manipulator to be drawn up through the reduction nut, pulling the bone fragment toward the reduction platform, thereby reducing the fracture.