发明授权
- 专利标题： High affinity human antibodies to human IL-18 receptor
- 专利标题（中）： 人类IL-18受体高亲和力抗体
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申请号： US11784308申请日： 2007-04-06
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公开(公告)号： US07615220B2公开(公告)日： 2009-11-10
- 发明人: Tammy H. Huang , Sean Stevens , Joel H. Martin , Jeanette L. Fairhurst , Kevin J. Pobursky , Margaret Karow , Joan A. Windsor , Warren R. Mikulka
- 申请人： Tammy H. Huang , Sean Stevens , Joel H. Martin , Jeanette L. Fairhurst , Kevin J. Pobursky , Margaret Karow , Joan A. Windsor , Warren R. Mikulka
- 申请人地址： US NY Tarrytown
- 专利权人： Regeneron Pharmaceuticals, Inc.
- 当前专利权人： Regeneron Pharmaceuticals, Inc.
- 当前专利权人地址： US NY Tarrytown
- 代理商 Valeta Gregg, Esq.
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/28
摘要：
An isolated antibody or antibody fragment that binds human interleukin-18 receptor alpha (hIL-18Rα), comprising a light chain variable region (LCVR) selected from the group consisting of SEQ ID NO: 5, 9, 13, 17, 21, 25, 29, 33, 37, 41, 45, 49, 53, 61, 65, 69, 73, 77, and 81 and/or a heavy chain variable region (HCVR) selected from the group consisting of SEQ ID NO: 3, 7, 11, 15, 19, 23, 27, 31, 35, 39, 43, 47, 51, 55, 59, 63, 67, 71, 75, and 79, or a fragment or sequence modified by an amino acid substitution, deletion or addition thereof.
公开/授权文献
- US20070237776A1 High affinity human antibodies to human IL-18 receptor 公开/授权日：2007-10-11
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