- 专利标题: Compounds which potentiate glutamate receptor and uses thereof in medicine
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申请号: US11573370申请日: 2005-08-05
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公开(公告)号: US07618969B2公开(公告)日: 2009-11-17
- 发明人: Daniel Marcus Bradley , Kevin Michael Thewlis , Simon Edward Ward
- 申请人: Daniel Marcus Bradley , Kevin Michael Thewlis , Simon Edward Ward
- 申请人地址: GB Middlesex
- 专利权人: Glaxo Group Limited
- 当前专利权人: Glaxo Group Limited
- 当前专利权人地址: GB Middlesex
- 代理商 James M. Kanagy; Edward R. Gimmi; Charles M. Kinzig
- 优先权: GB0417708.5 20040809; GB0508473.6 20050426
- 国际申请: PCT/EP2005/008562 WO 20050805
- 国际公布: WO2006/015828 WO 20060216
- 主分类号: A61K31/44
- IPC分类号: A61K31/44 ; C07D213/02
摘要:
Compounds of formula (I) or a pharmaceutically acceptable salt, solvate or prodrug thereof, are disclosed: wherein R1 is C1-6alkyl, haloC1-6alkyl, C2-6alkenyl, amino, monoC1-4alkylamino or diC1-4alkylamino; R2 and R3, which may be the same or different, are hydrogen, halogen, C1-6alkyl, haloC1-6alkyl, C1-4alkoxy, haloC1-4alkoxy, cyano, amino, monoC1-4alkylamino or diC1-4alkylamino; each R4, which may be the same or different, is C1-6alkyl, halogen, C1-6alkyl, haloC1-6alkyl, C1-4alkoxy, haloC1-4alkoxy, cyano, nitro, amino, monoC1-4alkylamino or diC1-4alkylamino; p is 0, 1 or 2; n is 1 or 2; R5 and R6, which may be the same or different, are hydrogen, halogen, C1-6alkyl, haloC1-6alkyl, C1-4alkoxy, haloC1-4alkoxy, cyano, amino, monoC1-4alkylamino or diC1-4alkylamino; and Het is thienyl, pyridyl, pyrimidinyl, pyridazinyl, pyrimidinyl, pyrazinyl, imidazolyl, pyrazolyl, pyrrolyl, quinolyl, thiazolyl or furyl, each of which may be substituted by one or more groups independently selected from the list consisting of C1-6alkyl, C1-6alkoxy, acetyl, halogen, haloC1-6alkyl, cyano, nitro, amino, monoC1-4alkylamino and diC1-4alkylamino. Methods of preparation of the compounds, and uses thereof in medicine, for example treatment of schizophrenia, are also disclosed.
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