发明授权
US07622501B2 Nitric oxide releasing prodrugs of diaryl-2-(5H)-furanones as cyclooxygenase-2 inhibitors
失效
二芳基-2-（5H） - 呋喃酮作为环加氧酶-2抑制剂的一氧化氮释放前药
- 专利标题： Nitric oxide releasing prodrugs of diaryl-2-(5H)-furanones as cyclooxygenase-2 inhibitors
- 专利标题（中）： 二芳基-2-（5H） - 呋喃酮作为环加氧酶-2抑制剂的一氧化氮释放前药
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申请号： US10586381申请日： 2005-01-25
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公开(公告)号： US07622501B2公开(公告)日： 2009-11-24
- 发明人: Claude Dufresne , Carl Berthelette , Lianhai Li , Daniel Guay , Michel Gallant , Patrick Lacombe , Renee Aspiotis , Zhaoyin Wang , Claudio F. Sturino
- 申请人： Claude Dufresne , Carl Berthelette , Lianhai Li , Daniel Guay , Michel Gallant , Patrick Lacombe , Renee Aspiotis , Zhaoyin Wang , Claudio F. Sturino
- 申请人地址： CA Kirkland, Province of Quebec
- 专利权人： Merck Frosst Canada & Co.
- 当前专利权人： Merck Frosst Canada & Co.
- 当前专利权人地址： CA Kirkland, Province of Quebec
- 代理商 Curtis C. Panzer; Valerie J. Camara
- 国际申请： PCT/CA2005/000083 WO 20050125
- 国际公布： WO2005/070883 WO 20050804
- 主分类号： A61K31/60
- IPC分类号： A61K31/60
摘要：
The invention encompasses novel compounds of Formula I, which are nitric oxide-releasing prodrugs of diaryl-2-(5H)-furanones useful in the treatment of cyclooxygenase-2 mediated diseases, Formula (I). The invention also encompasses certain pharmaceutical compositions and methods for treating cyclooxygenase-2 mediated diseases comprising the use of compounds of Formula 1. The above compounds may be used as a combination therapy with low-dose aspirin to treat chronic cyclooxygenase-2 mediated diseases or conditions while also reducing the risk of thrombotic cardiovascular events.