发明授权
US07622553B2 Rhesus monkey dickkopf-1, nucleotides encoding same, and uses thereof
失效
恒河猴dickkopf-1,编码相同的核苷酸及其用途
- 专利标题: Rhesus monkey dickkopf-1, nucleotides encoding same, and uses thereof
- 专利标题(中): 恒河猴dickkopf-1,编码相同的核苷酸及其用途
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申请号: US10579605申请日: 2004-11-12
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公开(公告)号: US07622553B2公开(公告)日: 2009-11-24
- 发明人: Shun-ichi Harada , Viera Kasparcova , Helmut Glantschnig
- 申请人: Shun-ichi Harada , Viera Kasparcova , Helmut Glantschnig
- 申请人地址: US NJ Rahway
- 专利权人: Merck & Co., Inc.
- 当前专利权人: Merck & Co., Inc.
- 当前专利权人地址: US NJ Rahway
- 代理商 Patricia L. Chisholm; Valerie J. Camara
- 国际申请: PCT/US2004/038489 WO 20041112
- 国际公布: WO2005/049640 WO 20050602
- 主分类号: C07K14/00
- IPC分类号: C07K14/00 ; C07K17/00 ; G01N33/53
摘要:
The present invention provides rhesus monkey dickkopf-1 (rhDkk-1) and nucleotide sequences encoding it. Also provided herein are recombinant vectors, and recombinant hosts comprising rhDkk-1-encoding nucleotide sequences. Isolated rhDkk-1 can be used to screen and identify novel osteoanabolic compounds that stimulate bone formation for the treatment of osteoporosis or other disorders characterized by insufficient bone mass.