发明授权
- 专利标题: Recombinant human interferon-like proteins
- 专利标题(中): 重组人干扰素样蛋白
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申请号: US11764786申请日: 2007-06-18
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公开(公告)号: US07625555B2公开(公告)日: 2009-12-01
- 发明人: Haitao Wang , Chunsheng Mao , Jizhi Li , Jing Xu , Rui Zhang , Ling Wang , Yong Du , Longbin Liu
- 申请人: Haitao Wang , Chunsheng Mao , Jizhi Li , Jing Xu , Rui Zhang , Ling Wang , Yong Du , Longbin Liu
- 申请人地址: KY George Town
- 专利权人: Novagen Holding Corporation
- 当前专利权人: Novagen Holding Corporation
- 当前专利权人地址: KY George Town
- 代理机构: Oyen Wiggs Green & Mutala LLP
- 主分类号: A61K38/21
- IPC分类号: A61K38/21 ; C07K14/00 ; C08H1/02 ; C12P21/04 ; C07H21/04 ; A61K38/00
摘要:
This application relates to recombinant human interferon-like proteins. In one embodiment a recombinant protein created by gene shuffling technology is described having enhanced anti-viral and anti-proliferative activities in comparison to naturally occurring human interferon alpha 2b (HuIFN-α2b). The invention encompasses a polynucleotide encoding the protein and recombinant vectors and host cells comprising the polynucleotide. Preferably the polynucleotide is selected from the group of polynucleotides each having a sequence at least 93% identical to SEQ ID: No. 1 and the protein is selected from the group of proteins each having an amino acid sequence at least 85% identical to SEQ ID No: 2. The proteins and compositions comprising the proteins can be used for treatment of conditions responsive to interferon therapy, such as viral diseases and cancer.
公开/授权文献
- US20080312148A1 RECOMBINANT HUMAN INTERFERON-LIKE PROTEINS 公开/授权日:2008-12-18