Invention Grant
US07625945B2 Andrographolide and analogues as inhibitors of TNFα and IL-1β expression
有权
穿心莲内酯和类似物作为TNFalpha和IL-1beta表达的抑制剂
- Patent Title: Andrographolide and analogues as inhibitors of TNFα and IL-1β expression
- Patent Title (中): 穿心莲内酯和类似物作为TNFalpha和IL-1beta表达的抑制剂
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Application No.: US11078198Application Date: 2005-03-11
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Publication No.: US07625945B2Publication Date: 2009-12-01
- Inventor: Xiaoqiang Yan , Tao Wang , Zhiming Ma , Ke Pan , Weihan Zhang , Jianrong Hong , Jeff Duan , Yu Cai
- Applicant: Xiaoqiang Yan , Tao Wang , Zhiming Ma , Ke Pan , Weihan Zhang , Jianrong Hong , Jeff Duan , Yu Cai
- Applicant Address: BS Nassau
- Assignee: Hutchison MediPharma Enterprises Ltd.
- Current Assignee: Hutchison MediPharma Enterprises Ltd.
- Current Assignee Address: BS Nassau
- Agency: Occhiuti Rohlicek & Tsao LLP
- Main IPC: A61K31/341
- IPC: A61K31/341
Abstract:
This invention relates to a method of inhibiting the expression of TNFα or IL-1β with a compound of the following formula: wherein R1 and R2 are defined herein. It also relates to is a method of treating inflammatory bowel disease with such a compound.
Public/Granted literature
- US20050215628A1 Andrographolide and analogues as inhibitors of TNFalpha and IL-1beta expression Public/Granted day:2005-09-29
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