Invention Grant
- Patent Title: AAV vector for gene therapy
- Patent Title (中): AAV载体用于基因治疗
-
Application No.: US10560268Application Date: 2004-06-09
-
Publication No.: US07629322B2Publication Date: 2009-12-08
- Inventor: Jürgon Kleinschmidt , Oliver Müller
- Applicant: Jürgon Kleinschmidt , Oliver Müller
- Agency: Howrey LLP
- Agent Viola T. Kung
- Priority: EP03013169 20030611
- International Application: PCT/EP2004/006222 WO 20040609
- International Announcement: WO2004/111248 WO 20041223
- Main IPC: A61K31/70
- IPC: A61K31/70 ; A61K48/00 ; C12N15/861
Abstract:
Described are recombinant AAV vectors characterized in that they carry capsid protein modification(s) resulting in a reduced or eliminated heparin binding function. The AAV vectors of the present invention are particularly suitable for gene therapy by systemic application, since (a) transduction of the liver is eliminated or at least drastically reduced and (b) the transduction efficiency of non-hepatic tissues is increased.
Public/Granted literature
- US20070036757A1 Aav vector for gene therapy Public/Granted day:2007-02-15
Information query
