发明授权
US07632813B2 Bone densifying agent characterized by use of cathepsin K inhibitor with PTH
失效
骨密集剂，其特征在于使用组织蛋白酶K抑制剂与PTH
- 专利标题： Bone densifying agent characterized by use of cathepsin K inhibitor with PTH
- 专利标题（中）： 骨密集剂，其特征在于使用组织蛋白酶K抑制剂与PTH
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申请号： US11587557申请日： 2005-04-25
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公开(公告)号： US07632813B2公开(公告)日： 2009-12-15
- 发明人: Yasuo Ochi , Makoto Tanaka , Naoki Kawada , Hiroyuki Yamada , Hiroshi Mori , Ryouji Kayasuga
- 申请人： Yasuo Ochi , Makoto Tanaka , Naoki Kawada , Hiroyuki Yamada , Hiroshi Mori , Ryouji Kayasuga
- 申请人地址： JP Osaka
- 专利权人： Ono Pharmaceutical Co., Ltd.
- 当前专利权人： Ono Pharmaceutical Co., Ltd.
- 当前专利权人地址： JP Osaka
- 代理机构： Sughrue Mion, PLLC
- 优先权： JP2004-129454 20040426
- 国际申请： PCT/JP2005/007767 WO 20050425
- 国际公布： WO2005/102381 WO 20051103
- 主分类号： A61K31/70
- IPC分类号： A61K31/70 ; A61K31/425
摘要：
The present invention relates to an agent for increasing BMD characterized by use of a cathepsin K inhibitor as a bone resorption inhibitor in combination with a type of PTH as a bone formation stimulator. This agent for increasing BMD is useful for the treatment of osteoporosis, bone fracture, arthritis, rheumatoid arthritis, osteoarthritis, hypercalcemia, osteometastasis of carcinoma, periodontal disease, bone Paget's disease and other bone metabolic diseases. For example, as the cathepsin K inhibitor, there can be mentioned a compound of formula (W) and a salt thereof, etc.
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