发明授权
US07645738B2 18-membered nitrobenzyl- and aminobenzyl-substituted cyclohexadepsipeptides for controlling endoparasites and a process for their preparation
失效
用于控制内寄生虫的18元硝基苄基 - 和氨基苄基取代的环己缩肽及其制备方法
- 专利标题： 18-membered nitrobenzyl- and aminobenzyl-substituted cyclohexadepsipeptides for controlling endoparasites and a process for their preparation
- 专利标题（中）： 用于控制内寄生虫的18元硝基苄基 - 和氨基苄基取代的环己缩肽及其制备方法
-
申请号： US10582555申请日： 2004-12-07
-
公开(公告)号： US07645738B2公开(公告)日： 2010-01-12
- 发明人: Peter Jeschke , Achim Harder
- 申请人： Peter Jeschke , Achim Harder
- 申请人地址： DE
- 专利权人： Bayer Animal Health GmbH
- 当前专利权人： Bayer Animal Health GmbH
- 当前专利权人地址： DE
- 代理商 Jessica Monachello
- 优先权： DE10359798 20031219
- 国际申请： PCT/EP2004/013896 WO 20041207
- 国际公布： WO2005/063277 WO 20050714
- 主分类号： A61K38/00
- IPC分类号： A61K38/00
摘要：
The invention relates to cyclic depsipeptides, especially 18-membered cyclohexadepsipeptides of general formula (I) and the salts thereof, wherein R1 represents nitrobenzyl or R′R″N-benzyl—wherein R′ and R″ independently represent hydrogen, optionally substituted C1-C4-alkyl, formyl, C1-C4-alkoxy-C1-C4-alkyl, C1-C4-alkoxycarbonyl, or hydroxy-C1-C2-alkyl-sulfonyl-C1-C2-alkyl, or, together with the nitrogen atom to which they are bound, R′ and R″ form an optionally substituted monocyclic or polycyclic, optionally bridged and/or spirocyclic, saturated or unsaturated heterocycle containing between one and three other heteroatoms from the group of nitrogen, oxygen and sulphur, or R′ and R″ together form C3-C5-alkylene monocarbonyl or an optionally substituted diacyl radical of a C4-C6-dicarboxylic acid—and R2, R3 and R4 independently represent C1-C4-alkyl. The invention also relates to the optical isomers and racemates of said cyclic depsipeptides, to a method for the production thereof, and to the use of the same for controlling endoparasites.