A power control system comprises a plurality of point-of-load (POL) regulators each adapted to convey regulated power to a load, a serial data bus operatively connecting the plurality of POL regulators, and a digital power manager connected to the data bus. The digital power manager includes a controller adapted to execute stored instructions to program operational parameters of the plurality of POL regulators via the serial data bus and receive monitoring data from the plurality of POL regulators via the serial data bus. The digital power manager further comprises a user interface, such as an I2C interface, adapted to receive programming data therefrom and send monitoring data thereto. The digital power manager further comprises a non-volatile memory containing a plurality of registers, including a digital power manager configuration register containing data values defining a configuration of the power control system, a POL set-up register containing data values reflecting programming state of one of the POL regulators, a POL monitor register containing data values reflecting status of operating conditions within one of the POL regulators, and a user-definable space. The digital power manager is adapted to program voltage margining of each of the POL regulators.