发明授权
US07649015B2 Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds
有权
HIV蛋白酶抑制剂化合物的膦酸酯类似物的细胞积累
- 专利标题： Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds
- 专利标题（中）： HIV蛋白酶抑制剂化合物的膦酸酯类似物的细胞积累
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申请号： US10423496申请日： 2003-04-25
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公开(公告)号： US07649015B2公开(公告)日： 2010-01-19
- 发明人: Murty N. Arimili , Xiaowu Chen , Maria Fardis , Gong-Xin He , Haolun Jin , Choung U. Kim , William A. Lee , Kuei-Ying Lin , Hongtao Liu , Richard L. Mackman , Michael L. Mitchell , Hyung-Jung Pyun , Mark Sparacino , Sundaramoorthi Swaminathan , Jianying Wang , Matthew A. Williams , Lianhong Xu , Zheng-Yu Yang , Richard H. Yu , Jiancun Zhang , Lijun Zhang
- 申请人： Murty N. Arimili , Xiaowu Chen , Maria Fardis , Gong-Xin He , Haolun Jin , Choung U. Kim , William A. Lee , Kuei-Ying Lin , Hongtao Liu , Richard L. Mackman , Michael L. Mitchell , Hyung-Jung Pyun , Mark Sparacino , Sundaramoorthi Swaminathan , Jianying Wang , Matthew A. Williams , Lianhong Xu , Zheng-Yu Yang , Richard H. Yu , Jiancun Zhang , Lijun Zhang
- 申请人地址： US CA Palo Alto
- 专利权人： Gilead Sciences, Inc.
- 当前专利权人： Gilead Sciences, Inc.
- 当前专利权人地址： US CA Palo Alto
- 代理机构： Gilead Sciences, Inc.
- 代理商 Max D. Hensley; Cynthia H. Zhang
- 主分类号： A61K31/343
- IPC分类号： A61K31/343 ; C07F9/28
摘要：
Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.
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