发明授权
US07652024B2 Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
失效
酰基化螺哌啶衍生物作为黑皮质素-4受体调节剂
- 专利标题： Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
- 专利标题（中）： 酰基化螺哌啶衍生物作为黑皮质素-4受体调节剂
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申请号： US12083567申请日： 2006-10-13
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公开(公告)号： US07652024B2公开(公告)日： 2010-01-26
- 发明人: Raman K. Bakshi , James P. Dellureficio , Peter H. Dobbelaar , Liangqin Guo , Shuwen He , Qingmei Hong , Ravi P. Nargund , Zhixiong Ye
- 申请人： Raman K. Bakshi , James P. Dellureficio , Peter H. Dobbelaar , Liangqin Guo , Shuwen He , Qingmei Hong , Ravi P. Nargund , Zhixiong Ye
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Baerbel R. Brown; Richard C. Billups; Catherine D. Fitch
- 国际申请： PCT/US2006/040198 WO 20061013
- 国际公布： WO2007/047496 WO 20070426
- 主分类号： A61K31/438
- IPC分类号： A61K31/438 ; C07D491/107
摘要：
Certain novel N-acylated spiropiperidine derivatives are ligands of the human melanocortin receptor(s) and, in particular, are selective ligands of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of MC-4R, such as obesity, diabetes, nicotine addiction, alcoholism, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.
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