发明授权
US07652063B2 10-hydroxy-11-dihydroprostaglandin analogs as selective EP4 agonists
有权
10-羟基-11-二氢前列腺素类似物作为选择性EP4激动剂
- 专利标题： 10-hydroxy-11-dihydroprostaglandin analogs as selective EP4 agonists
- 专利标题（中）： 10-羟基-11-二氢前列腺素类似物作为选择性EP4激动剂
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申请号： US11532404申请日： 2006-09-15
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公开(公告)号： US07652063B2公开(公告)日： 2010-01-26
- 发明人: Yariv Donde
- 申请人： Yariv Donde
- 申请人地址： US CA Irvine
- 专利权人： Allergan, Inc.
- 当前专利权人： Allergan, Inc.
- 当前专利权人地址： US CA Irvine
- 代理机构： Allergan, Inc.
- 代理商 John E. Wurst; Kevin J. Forrestal
- 主分类号： A61K31/38
- IPC分类号： A61K31/38 ; A61K31/557 ; C07D333/56 ; C07C59/185
摘要：
A compound comprising or a pharmaceutically acceptable salt or a prodrug thereof, wherein the dashed line represents the presence or absence of a double bond; J is C═O or CHOH; A is —(CH2)6—, or cis —CH2CH═CH—(CH2)3—, wherein 1 or 2 carbons may be substituted with S or O; B is CO2H, or CO2R, CONR2, CONHCH2CH2OH, CON(CH2CH2OH)2, CH2OR, P(O)(OR)2, CONRSO2R, SONR2, or R is H, C1-6 alkyl; D is —(CH2)n—, —X(CH2)n, or —(CH2)nX—, wherein n is from 0 to 3 and X is S or O; and E is an aromatic or heteroaromatic moiety having from 0 to 4 substituents, said substituents each comprising from 1 to 6 non-hydrogen atoms is disclosed herein. Methods, compositions, and medicaments related thereto, as well as experimental results showing prostaglandin EP4 selective agonist activity for certain compounds disclosed herein, are also disclosed.
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