发明授权
US07655632B2 Pyrazole derivative, medicinal composition containing the same, medicinal use thereof, and intermediate for production thereof
失效
吡唑衍生物,含有该吡唑衍生物的药物组合物,其医药用途及其生产用中间体
- 专利标题: Pyrazole derivative, medicinal composition containing the same, medicinal use thereof, and intermediate for production thereof
- 专利标题(中): 吡唑衍生物,含有该吡唑衍生物的药物组合物,其医药用途及其生产用中间体
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申请号: US12104890申请日: 2008-04-17
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公开(公告)号: US07655632B2公开(公告)日: 2010-02-02
- 发明人: Hirotaka Teranishi , Nobuhiko Fushimi , Shigeru Yonekubo , Kazuo Shimizu , Toshihide Shibazaki , Masayuki Isaji
- 申请人: Hirotaka Teranishi , Nobuhiko Fushimi , Shigeru Yonekubo , Kazuo Shimizu , Toshihide Shibazaki , Masayuki Isaji
- 申请人地址: JP Nagano
- 专利权人: Kissei Pharmaceutical Co., Ltd.
- 当前专利权人: Kissei Pharmaceutical Co., Ltd.
- 当前专利权人地址: JP Nagano
- 代理机构: Sughrue Mion, PLLC
- 优先权: JP2002-232074 20020808; JP2002-321729 20021105
- 主分类号: A01N43/04
- IPC分类号: A01N43/04 ; A61K31/70
摘要:
The present invention provides pyrazole derivatives represented by the general formula: wherein R1 represents H, an optionally substituted C1-6 alkyl group etc.; one of Q and T represents a group represented by the general formula: or a group represented by the general formula: while the other represents an optionally substituted C1-6 alkyl group etc.; R2 represents H, a halogen atom, OH, an optionally substituted C1-6 alkyl group etc.; X represents a single bond, O or S; Y represents a single bond, a C1-6 alkylene group etc.; Z represents CO or SO2; R4 and R5 represent H, an optionally substituted C1-6 alkyl group etc.; and R3, R6 and R7 represent H, a halogen atom etc., pharmaceutically acceptable salts thereof or prodrugs thereof, which exhibit an excellent inhibitory activity in human SGLT1 and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, and pharmaceutical compositions comprising the same, pharmaceutical uses thereof, and intermediates for production thereof.
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