发明授权
US07657380B2 Methods of generating variant antibodies with increased host string content
有权
产生具有增加的宿主串含量的变体抗体的方法
- 专利标题： Methods of generating variant antibodies with increased host string content
- 专利标题（中）： 产生具有增加的宿主串含量的变体抗体的方法
-
申请号： US11004590申请日： 2004-12-03
-
公开(公告)号： US07657380B2公开(公告)日： 2010-02-02
- 发明人: Gregory Alan Lazar , John R. Desjarlais , Philip W. Hammond
- 申请人： Gregory Alan Lazar , John R. Desjarlais , Philip W. Hammond
- 申请人地址： US CA Monrovia
- 专利权人： Xencor, Inc.
- 当前专利权人： Xencor, Inc.
- 当前专利权人地址： US CA Monrovia
- 代理机构： Morgan Lewis & Bockius LLP
- 代理商 Robin M. Silva, Esq.; David C. Foster, Esq.
- 主分类号： G01N33/48
- IPC分类号： G01N33/48 ; C12Q1/68 ; C12P21/08
摘要：
The present invention relates to novel methods for generating variant proteins with increased host string content by comparing a parent protein sequence with two or more natural protein sequences from a host species, analyzing one or more amino acid strings of the parent protein sequence with a structurally corresponding amino acid string of each of said natural protein sequences, substituting one or more amino acid strings of the parent protein sequence with a structurally corresponding amino acid string of one of the two or more natural protein sequences on an amino acid string by amino acid string basis so that the variant protein has increased host string content, and, synthesizing and screening the variant protein.
公开/授权文献
信息查询
