发明授权
- 专利标题： Mutant forms of cholera holotoxin as an adjuvant
- 专利标题（中）： 霍乱全毒素作为佐剂的突变形式
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申请号： US11960226申请日： 2007-12-19
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公开(公告)号： US07658931B2公开(公告)日： 2010-02-09
- 发明人: Bruce A. Green , Randall K. Holmes , Michael G. Jobling , Duzhang Zhu
- 申请人： Bruce A. Green , Randall K. Holmes , Michael G. Jobling , Duzhang Zhu
- 申请人地址： US NJ Madison US DC Washington
- 专利权人： Wyeth Holdings Corporation,The United States of America, as represented by the Uniformed Services University of Health Sciences
- 当前专利权人： Wyeth Holdings Corporation,The United States of America, as represented by the Uniformed Services University of Health Sciences
- 当前专利权人地址： US NJ Madison US DC Washington
- 代理机构： Howson & Howson LLP
- 代理商 J. Darrell Fontenot
- 主分类号： C07K14/28
- IPC分类号： C07K14/28 ; A61K39/106
摘要：
Mutant cholera holotoxins having single or double amino acid substitutions or insertions have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in antigenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self-molecule.
公开/授权文献
- US20080311144A1 MUTANT FORMS OF CHOLERA HOLOTOXIN AS AN ADJUVANT 公开/授权日：2008-12-18
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