发明授权
- 专利标题: Macrocylic inhibitors of hepatitis C virus
- 专利标题(中): 丙型肝炎病毒的大肠杆菌抑制剂
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申请号: US11995900申请日: 2006-07-28
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公开(公告)号: US07659245B2公开(公告)日: 2010-02-09
- 发明人: Kenneth Alan Simmen , Herman Augustinus De Kock , Pierre Jean-Marie Bernard Raboisson , Lili Hu , Karin Charlotta Lindquist , Mats Stefan Lindström , Anna Karin Gertrud Linnea Belfrage , Horst Jürgen Wähling , Karl Magnus Nilsson , Bengt Bertil Samuelsson , Åsa Annica Kristina Rosenquist , Sven Crister Sahlberg , Hans Kristian Wallberg , Pia Cecilia Kahnberg , Björn Olof Classon
- 申请人: Kenneth Alan Simmen , Herman Augustinus De Kock , Pierre Jean-Marie Bernard Raboisson , Lili Hu , Karin Charlotta Lindquist , Mats Stefan Lindström , Anna Karin Gertrud Linnea Belfrage , Horst Jürgen Wähling , Karl Magnus Nilsson , Bengt Bertil Samuelsson , Åsa Annica Kristina Rosenquist , Sven Crister Sahlberg , Hans Kristian Wallberg , Pia Cecilia Kahnberg , Björn Olof Classon
- 申请人地址: IE
- 专利权人: Tibotec Pharmaceuticals Ltd
- 当前专利权人: Tibotec Pharmaceuticals Ltd
- 当前专利权人地址: IE
- 优先权: EP05107057 20050729; EP06113097 20060425
- 国际申请: PCT/EP2006/064822 WO 20060728
- 国际公布: WO2007/014927 WO 20070208
- 主分类号: A61K38/00
- IPC分类号: A61K38/00
摘要:
Compounds of the formula I: and N-oxides, salts, and stereoisomers thereof wherein A is OR1, NHS(═O)pR2; wherein; R1 is hydrogen, C1-C6alkyl, C0-C3alkylenecarbocyclyl, C0-C3alkylene-heterocyclyl; R2 is C1-C6alkyl, C0-C3alkylenecarbocyclyl, C0-C3alkyleneheterocyclyl; p is independently 1 or 2; n is 3, 4, 5 or 6; denotes an optional double bond; L is N or CRz; Rz is H or forms a double bond with the asterisked carbon; Rq is H or when L is CRz, Rq can also be C1-C6alkyl; Rr is quinazolinyl, optionally substituted with one two or three substituents each independently selected from C1-C6 alkyl, C1-C6alkoxy, hydroxyl, halo, haloC1-C6alkyl, amino, mono- or dialkylamino, mono- or dialkylaminocarbonyl, C1-C6alkyl-carbonylamino, C0-C3alkylenecarbocyclyl and C0-C3 alkyleneheterocyclyl; R5 is hydrogen, C1-C6alkyl, C1-C6alkoxyC1-C6alkyl or C3-C7cycloalkyl; R6 is hydrogen, C1-C6alkyl, C1-C6alkoxy, C0-C3alkylenecarbocyclyl, C0-C3alkylene-heterocyclyl, hydroxy, bromo, chloro or fluoro have utility in the treatment or prophylaxis of flaviviral infections such as HCV.
公开/授权文献
- US20090118312A1 Macrocylic Inhibitors of Hepatitis C Virus 公开/授权日:2009-05-07
信息查询
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