发明授权
- 专利标题: Synthesis of intermediates for the preparation of pramipexol
- 专利标题(中): 用于制备普拉克索的中间体的合成
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申请号: US11622259申请日: 2007-01-11
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公开(公告)号: US07662610B2公开(公告)日: 2010-02-16
- 发明人: Sergio Riva , Paola Fassi , Michele Scarpellini , Pietro Allegrini , Gabriele Razzetti
- 申请人: Sergio Riva , Paola Fassi , Michele Scarpellini , Pietro Allegrini , Gabriele Razzetti
- 申请人地址: IT Baranzate
- 专利权人: Dipharma Francis s.r.l.
- 当前专利权人: Dipharma Francis s.r.l.
- 当前专利权人地址: IT Baranzate
- 代理机构: Griffin & Szipl, P.C.
- 优先权: ITMI2006A0044 20060113
- 主分类号: C12P41/00
- IPC分类号: C12P41/00
摘要:
A process for the preparation of an acid of formula (I), as the individual (R) enantiomer or (S), or a salt thereof wherein R is a protected amino group; and the asterisk * denotes the stereogenic carbon atom, comprising contacting an ester of formula (II), as mixture of (R,S) enantiomers, or a salt thereof, wherein R1 is straight or branched C1-C6 alkyl, optionally substituted with phenyl; (the asterisk * and R defined above), with a lipase from Candida antarctica, under conditions effective to obtain a mixture comprising an acid of formula (I), as the individual (R) enantiomer, and an ester of formula (II), as the individual (S) enantiomer; the subsequent hydrolysis of the latter to obtain an acid of formula (I), as the individual (S) enantiomer; and, if desired, the conversion of an acid of formula (I), either as the (R) or (S) enantiomer, to a salt thereof.
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