Invention Grant
- Patent Title: Process for the preparation of Fluvastatin Sodium salt
- Patent Title (中): 氟伐他汀钠盐的制备方法
-
Application No.: US11785702Application Date: 2007-04-19
-
Publication No.: US07662848B2Publication Date: 2010-02-16
- Inventor: Marco Fachini
- Applicant: Marco Fachini
- Applicant Address: IT Alte Di Montecchio Maggiore (Vicenza)
- Assignee: F.I.S. Fabbrica Italiana Sintetici S.p.A.
- Current Assignee: F.I.S. Fabbrica Italiana Sintetici S.p.A.
- Current Assignee Address: IT Alte Di Montecchio Maggiore (Vicenza)
- Agency: Dickstein Shapiro LLP
- Priority: EP06112856 20060420
- Main IPC: A61K31/404
- IPC: A61K31/404
Abstract:
The present invention is directed to a process for preparing Fluvastatin Sodium salt by basic hydrolysis of its alkyl ester. The reaction is performed in conditions suitable to allow a selective hydrolysis of the desired syn isomer, while the unwanted anti isomer is removed by extraction, thus reducing its content in the final product; this diastereomer is the main impurity of Fluvastatin sodium salt and its ester precursor.
Public/Granted literature
- US20070249704A1 Process for the preparation of fluvastatin sodium salt Public/Granted day:2007-10-25
Information query
IPC分类:
