Invention Grant
- Patent Title: Peptides having protected amines of untargeted sites, methods for production thereof and of specifically conjugated PEG peptides using the same
- Patent Title (中): 具有非靶向位点的保护胺的肽,其制备方法和使用其的特异性缀合的PEG肽
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Application No.: US10542230Application Date: 2003-01-18
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Publication No.: US07662915B2Publication Date: 2010-02-16
- Inventor: Sang Deuk Lee , Kang Choon Lee , Dong Hee Na , Yu Seok Youn
- Applicant: Sang Deuk Lee , Kang Choon Lee , Dong Hee Na , Yu Seok Youn
- Applicant Address: KR Suwon
- Assignee: Pegsphere Co., Ltd.
- Current Assignee: Pegsphere Co., Ltd.
- Current Assignee Address: KR Suwon
- Agency: Heslin Rothenberg Farley & Mesiti P.C.
- International Application: PCT/KR03/00118 WO 20030118
- International Announcement: WO2004/065412 WO 20040805
- Main IPC: C07K1/06
- IPC: C07K1/06 ; C07K1/107 ; C07K1/04 ; C07K1/00

Abstract:
The present invention relates to synthetic peptides having selectively protected amines of untargeted sites and to methods for production thereof and for specifically conjugating PEG to targeted sites of the synthetic peptides using the same. The present invention provides a much higher yield of PEG conjugated peptides in which PEG is specifically combined to amines at targeted sites.
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