发明授权
US07666626B2 Mutants of the P4 protein of nontypable Haemophilus influenzae with reduced enzymatic activity
失效
不良型流感嗜血杆菌P4蛋白的突变体具有降低的酶活性
- 专利标题： Mutants of the P4 protein of nontypable Haemophilus influenzae with reduced enzymatic activity
- 专利标题（中）： 不良型流感嗜血杆菌P4蛋白的突变体具有降低的酶活性
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申请号： US12336995申请日： 2008-12-17
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公开(公告)号： US07666626B2公开(公告)日： 2010-02-23
- 发明人: Bruce A. Green , Gary W. Zlotnick , Leah D. Fletcher , Arnold L. Smith , Thomas J. Reilly
- 申请人： Bruce A. Green , Gary W. Zlotnick , Leah D. Fletcher , Arnold L. Smith , Thomas J. Reilly
- 申请人地址： US NJ Madison US MO Columbia
- 专利权人： Wyeth Holdings Corporation,The Curators of the University of Missouri
- 当前专利权人： Wyeth Holdings Corporation,The Curators of the University of Missouri
- 当前专利权人地址： US NJ Madison US MO Columbia
- 代理机构： Howson & Howson LLP
- 代理商 Alan M. Gordon, Esq.
- 主分类号： C12P21/06
- IPC分类号： C12P21/06
摘要：
A P4 variant protein that has reduced enzymatic activity and that induces antibody to wild-type P4 protein and/or has good bactericidal activity against non-typable H. influenzae (NTHi) is useful as an active component in an immunogenic composition for humans. Methods of using these proteins, and compositions containing them in combination with additional antigens, are also provided.
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