发明授权
- 专利标题: Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same
- 专利标题(中): 制备用于治疗和诊断应用的多价构建体的方法及其制备方法
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申请号: US10916155申请日: 2004-08-11
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公开(公告)号: US07666979B2公开(公告)日: 2010-02-23
- 发明人: Hong Fan , Edmund R. Marinelli , Palaniappa Nanjappan , Radhakrishna Pillai , Rolf E. Swenson
- 申请人: Hong Fan , Edmund R. Marinelli , Palaniappa Nanjappan , Radhakrishna Pillai , Rolf E. Swenson
- 申请人地址: NL Amsterdam
- 专利权人: Bracco International B.V.
- 当前专利权人: Bracco International B.V.
- 当前专利权人地址: NL Amsterdam
- 代理商 M. Caragh Noone
- 主分类号: C07K4/00
- IPC分类号: C07K4/00 ; C07K1/00
摘要:
Methods for the preparation of multivalent constructs for therapeutic and diagnostic applications are provided. More specifically, novel methods for preparing multivalent constructs comprising the formula A-B-C-D-E-B′-F for therapeutic and diagnostic applications are provided which use a novel linker D comprising, in various embodiments, a dicarboxylic acid derivative such as, e.g., a glutaric acid bis N-hydroxysuccinimidyl ester or a derivative thereof; or a diamine derivative.The remaining components in the multivalent construct A-B-C-D-E-B′-F are defined as follows: A is a first peptide, B is a first branching group, C is an optional first spacer, E is an optional second spacer which may be the same as or different from said first spacer C, B′ is an optional second branching group which may be the same as or different from said first branching group B, and F is a second peptide which may be the same as or different from said first peptide A.