发明授权
- 专利标题： Methods for enhancing neuroprotection via administration of stem cells and blood brain barrier permeabilizers
- 专利标题（中）： 通过施用干细胞和血脑屏障渗透剂增强神经保护作用的方法
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申请号： US11012849申请日： 2004-12-15
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公开(公告)号： US07674457B2公开(公告)日： 2010-03-09
- 发明人: Cesario V Borlongan , Paul R. Sanberg
- 申请人： Cesario V Borlongan , Paul R. Sanberg
- 申请人地址： US FL Tampa
- 专利权人： University of South Florida
- 当前专利权人： University of South Florida
- 当前专利权人地址： US FL Tampa
- 代理机构： Smith & Hopen, P.A.
- 代理商 Robert Varkonyi
- 主分类号： A61K35/14
- IPC分类号： A61K35/14 ; A61K31/047
摘要：
The present invention provides compositions and methods for enhancing the neuroprotective effect of umbilical cord blood cells. More particularly, the present invention provides methods of treating neurodegenerative disorders by administering umbilical cord blood cells and a substance capable of permeabilizing the blood brain barrier. In one embodiment, the blood brain barrier permeabilizer is mannitol. In another embodiment, the blood brain barrier permeabilizer is Cereport.