Invention Grant
- Patent Title: Compounds
- Patent Title (中): 化合物
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Application No.: US11389112Application Date: 2006-03-24
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Publication No.: US07674789B2Publication Date: 2010-03-09
- Inventor: James F. Callahan , Zehong Wan , Hongxing Yan , Xichen Lin
- Applicant: James F. Callahan , Zehong Wan , Hongxing Yan , Xichen Lin
- Applicant Address: GB Greenford, Middlesex
- Assignee: Glaxo Group Limited
- Current Assignee: Glaxo Group Limited
- Current Assignee Address: GB Greenford, Middlesex
- Agent Dara L. Dinner; Charles M. Kinzig; Theodore R. Furman
- Main IPC: A61K31/5355
- IPC: A61K31/5355 ; A61K31/519 ; C07D487/04 ; A61P29/00 ; C07D239/30 ; C07D239/38

Abstract:
The present invention is directed to compounds of formula (I), (Ia),(Ic) and (Id), compositions, and uses thereof as an inhibitor of the p38 kinase, and wherein, inter alia R1 is C(Z)N(R10′)(CR10R20)vRb, C(Z)O(CR10R20)vRb, N(R10′)C(Z)(CR10R20)vRb; N(R10′)C(Z)N(R10′)(CR10R20)vRb; or N(R10′)OC(Z)(CR10R20)vRb; R3 is C1-10 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl C1-10 alkyl, aryl, arylC1-10 alkyl, heteroarylC1-10 alkyl, or a heterocyclylC1-10 alkyl moiety, and wherein each of these moieties may be optionally substituted; X is R2, OR2′, S(O)mR2′, (CH2)n′N(R10′)S(O)mR2′, (CH2)n′N(R10′)C(O)R2′, (CH2)n′NR4R14, (CH2)n′N(R2 ′)(R2″), or N(R10′)—Rh—NH—C(═N—CN)NRqRq′; and R2 is hydrogen, C1-10 alkyl, C3-7 cycloalkyl, C3-7 cycloalkylalkyl, aryl, arylC1-10 alkyl, heteroaryl, heteroarylC1-10 alkyl, heterocyclic, or a heterocyclylC1-10 alkyl moiety, and wherein each of these moieties, excluding hydrogen, may be optionally substituted; or a pharmaceutically acceptable salt thereof.
Public/Granted literature
- US20060235030A1 Novel compounds Public/Granted day:2006-10-19
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