Invention Grant
US07678798B2 Piperazinylpiperidine derivatives as chemokine receptor antagonists
有权
哌嗪基哌啶衍生物作为趋化因子受体拮抗剂
- Patent Title: Piperazinylpiperidine derivatives as chemokine receptor antagonists
- Patent Title (中): 哌嗪基哌啶衍生物作为趋化因子受体拮抗剂
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Application No.: US11104041Application Date: 2005-04-12
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Publication No.: US07678798B2Publication Date: 2010-03-16
- Inventor: Chu-Biao Xue , Ganfeng Cao , Taisheng Huang , Lihua Chen , Ke Zhang , Anlai Wang , David Meloni , Rajan Anand , Joseph Glenn , Brian W. Metcalf
- Applicant: Chu-Biao Xue , Ganfeng Cao , Taisheng Huang , Lihua Chen , Ke Zhang , Anlai Wang , David Meloni , Rajan Anand , Joseph Glenn , Brian W. Metcalf
- Applicant Address: US DE Wilmington
- Assignee: Incyte Corporation
- Current Assignee: Incyte Corporation
- Current Assignee Address: US DE Wilmington
- Agency: Fish & Richardson P.C.
- Agent Christine A. Goddard
- Main IPC: A61K31/497
- IPC: A61K31/497 ; C07D247/02 ; A61K31/496 ; A61P29/00 ; C07D237/28 ; C07D487/00 ; C07D401/04 ; C07D403/04 ; C07D405/04 ; C07D409/04 ; C07D411/04 ; C07D413/04 ; C07D417/04 ; C07D419/04 ; C07D241/04 ; C07D277/22 ; C07D307/78 ; C07D303/08 ; C07C49/297 ; C07C33/46
Abstract:
The present invention relates to compounds of Formula I: wherein variable substituents are defined herein, that modulate the activity of or bind to chemokine receptors such as CCR5. In some embodiments, the compounds of the invention are selective for CCR5. The compounds can be used, for example, to treat diseases associated with chemokine receptor expression or activity such as inflammatory diseases, immune diseases and viral infections.
Public/Granted literature
- US20050261310A1 Piperazinylpiperidine derivatives as chemokine receptor antagonists Public/Granted day:2005-11-24
Information query
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